SH3P7/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport
نویسندگان
چکیده
منابع مشابه
SH3P7/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport.
The intracellular adaptor protein SH3P7 is the mammalian ortholog of yeast actin-binding protein 1 and thus alternatively named as mAbp1 (or HIP55). Structural properties, biochemical analysis of its interaction partners and siRNA studies implicated mAbp1 as an accessory protein in clathrin-mediated endocytosis (CME). Here, we describe the generation and characterization of mice deficient for S...
متن کاملMisdirection leads the way to vesicle transport proteins
Misdirection leads the way to vesicle transpor t proteins Bentley et al. use a novel assay to identify the kinesin motor proteins that bind to different types of endosomes. Membrane traf-fi cking is controlled by a large number of proteins that bind to spe-cifi c vesicles and organelles. But defi ning which proteins bind to which membranes within a crowded cell—by fl uorescence co-localization,...
متن کاملSmooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility
As a master component of endosomal sorting complex required for transport proteins, hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) participates multiple cellular behaviors. However, the physiological role of Hgs in smooth muscle cells (SMCs) is by far unknown. Here we explored the in vivo function of Hgs in SMCs by using a conditional gene knockout strategy. Hgs deficiency i...
متن کاملPICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here, we identify the lipid binding BAR (Bin/amphiphysin/Rvs) domain protein PICK1 (protein interacting ...
متن کاملDeficiency in ethanolamine plasmalogen leads to altered cholesterol transport.
Plasmalogens are a major sub-class of ethanolamine and choline phospholipids in which the sn-1 position has a long chain fatty alcohol attached through a vinyl ether bond. These phospholipids are proposed to play a role in membrane fusion-mediated events. In this study, we investigated the role of the ethanolamine plasmalogen plasmenylethanolamine (PlsEtn) in intracellular cholesterol transport...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2006
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7601053